The rash of urticaria is usually bumpy, red and itchy.
This may occur through anallergic processor one in which mast cells release chemicals without IgE being involved.
Unlike acute urticaria, only about 5 to 10 percent of chronic urticaria and angioedema are resulting from allergies.
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CIU much more likely to be related to autoimmune causes than allergies.
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The main treatment for CIU is with oralantihistamines.
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What Is Xolair?
It is these chemicals that cause worsening of asthma and other allergy symptoms, including urticaria and angioedema.
Can Xolair Be Used to Treat Chronic Urticaria?
Early studies are certainly promising.
A number of different studies examined the benefit of Xolair for the treatment of CIU.
They were administered Xolair in various dosages every 4 weeks.
Symptoms slowly worsened after Xolair was stopped, so there was no sign of long-term benefit.
Seventy-percent of people receiving Xolair had complete resolution of their CIU symptoms.
The U.S. Food and Drug Administration approved the use of Xolair for CIU in March 2014.
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2017;72(4):519-533. doi:10.1111/all.13083
