Histamine is a chemical released by immune cells when the body reacts to allergens or infections.
In people with histamine intolerance, the body cant break down this chemical properly.
Some believe that rising estrogen levels during ovulation may trigger a histamine surge, leading to PMDD symptoms.
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What Is the Connection Between Antihistamines and PMDD?
Antihistaminemedicines block histamine receptors and are categorized as either H1 or H2 blockers depending on their target receptors.
Its not specific hormone levels, but rather normal changes that seem to be the culprit, said Riddle.
Is It Risky to Take Pepcid AC or Zyrtec for PMDD?
Unless you are allergic to these medicines, theyre generally safe to try.
Known side effects of antihistamines include dry mouth, dizziness, and constipation.
What Do Experts Recommend for PMDD Relief?
Birth control pills containing ethinyl estradiol and drospirenone can also be helpful for some people because theysuppress ovulation.
Adopting healthy lifestyle habits may also provide some relief.
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