Two of the most common pain medications andfeverreducers areacetaminophenandibuprofen.
Still, there are some significant differences between acetaminophen and ibuprofen.
It belongs to a class of medications known asnonsteroidal anti-inflammatory drugs(NSAIDs).
Oleksandra Troian / Getty Images
Maximum daily dosesdepend on whether you take prescription-strength ibuprofen or over-the-counter (OTC) varieties.
Ibuprofen has different strengths, so read the label carefully and ask your provider if you have any questions.
Brand Names of Acetaminophen
Acetaminophen is a part of combination OTC products sold under several names.
However, some research points to a more direct mechanism.
The maximum daily dosage of this medication is 3,250 mg for adults and 1,625 mg for children.
Severe liver damage can occur if:
Notably, acetaminophen comes in different forms and strengths.
Double-check your dosage and use any medications only as directed.
If youve taken more than the recommended maximum amount, get medical help immediately.
What Is the Safest Pain Reliever to Use?
Ibuprofen and acetaminophen are considered safe for most people when taken correctly.
Acetaminophen Side Effects
As with other drugs, there are someside effects associated with acetaminophen.
Signs of this include:
Ibuprofen Side Effects
Ibuprofen also can cause some adverse effects.
Common side effects include:
In addition, there are several serious side effects.
Call 911 if you experience:
Which Is Worse for Your Liver: Tylenol or Ibuprofen?
It has been linked to nearly half of overdose-related acute liver failure cases in the United States.
Which Is Worse for Your Stomach?
Too much ibuprofen can damage and erode the stomach lining, causingulcersandbleeding.
Compared to acetaminophen, its much tougher on this body part.
Compared to acetaminophen, ibuprofen may be more damaging to the kidneys.
When to Use Ibuprofen vs. Acetaminophen
Ibuprofen is effective for pain and inflammation.
In contrast, acetaminophen acts on pain processing in the brain; both reduce fever.
Since acetaminophen is not an anti-inflammatory drug, it wont be as effective.
Ibuprofen is a pain reliever and an anti-inflammatory drug, whereas acetaminophen acts on pain.
There may be a benefit if the two are taken together.
In 2020, the Food and Drug Administration (FDA) approved an over-the-counter combination drug called Dual Action.
Advil and Tylenol are effective for mild pain.
However, some research has found Advil to be more effective than Tylenol.
After taking acetaminophen, the medication must reach your digestive system.
Stay upright immediately after taking the medication to confirm the it makes it to your stomach.
This can also damage your esophagus (food tube) and cause irritation.
US National Library of Medicine.Label: Tylenol regular strength: acetaminophen tablet.
Rainsford KD.History and development of ibuprofen.
In: Rainsford KD, ed.Ibuprofen.
John Wiley & Sons, Ltd; 2015:1-21.
National Library of Medicine Medline Plus.Ibuprofen.
Mazaleuskaya LL, Theken KN, Gong L, et al.PharmGKB summary: ibuprofen pathways.Pharmacogenet Genomics.
2015;25(2):96-106. doi:10.1097/FPC.0000000000000113
US Food and Drug Administration.Ibuprofen: drug facts label.
US National Library of Medicine.Label: Advil: ibuprofen tablet coated.
2016;4(2):131-142. doi:10.14218/JCTH.2015.00052
US Food and Drug Administration.NDA approval.
2015;19(9):1213-1223.
Johns Hopkins Medicine.Medicines and the digestive system.