Unipolar depression is another name for major depressive disorder.

While there is some symptom overlap between the two conditions, there are notable differences.

People with unipolar depression dont experience manic or hypomanic episodes.

Depressed woman

FG Trade / Getty Images

There are also important treatment differences.

Well also cover what to know about recurrent and treatment-resistant unipolar depression episodes.

It is another name for major depressive disorder.

When online, visit988lifeline.orgfor its chat line.

The Substance Abuse and Mental Health Services Administration (SAMHSA) can also help by calling800-662-HELP (4357).

The most significant difference between unipolar depression and bipolar disorder is the presence or absence of mania or hypomania.

Hypomania is a milder form of mania but can also be highly disruptive to a persons everyday functioning.

They also report a lower quality of life despite receiving significantly more treatment.

Symptom Similarities

People living with unipolar depression and people experiencing bipolar depression episodes share similar experiences.

People can be diagnosed with treatment-resistant depression after trying two different antidepressant medications without symptoms resolving.

However, a lack of response to typical depression treatment may also be a sign of bipolar disorder.

Summary

Both unipolar depression and bipolar disorder are characterized by depressive episodes.

Someone with bipolar disorder will also experience episodes of mania or hypomania.

Treatment approaches differ; unipolar depression is treated with antidepressants and bipolar depression is treated with mood stabilizers.

Recurrent depression increases the risk of disability, suicide, and comorbid conditions.

National Institute of Mental Health.Depression.

Here’s what experts say.

2020;32(10):703. doi:10.1097/JXX.0000000000000499

World Health Organization.Depressive disorder (depression).

American Psychiatric Association.What are bipolar disorders?

Voineskos D, Daskalakis ZJ, Blumberger DM.Management of treatment-resistant depression: challenges and strategies.Neuropsychiatr Dis Treat.

doi:10.1371/journal.pone.0230363

American Association of Suicidology.Some facts about suicide and depression.