it’s possible for you to develop a drug tolerance to any drug, regardless of its purpose.
While drug tolerance can be a challenge, solutions are available.
Your healthcare provider can conduct regular exams to reevaluate your treatment plan and reduce the incidence of drug tolerance.
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While drug tolerance can occur with either condition, it can also exist as a separate condition.
you might develop a high tolerance if you take a substance or drug regularly.
It can also occur as a result of genetics.
While there is a difference between addiction and dependence, addiction often follows dependence.
When used as prescribed, drug tolerance is unknown.
Some people may have a natural tolerance to certain drugs or drug types as a result of genetics.
However, it’s unclear why others develop an acquired drug tolerance.
External factors, such asstress, that impact your psychological condition, can contribute to drug tolerance.
Behavioral
Behavioral tolerance suggests that you become conditioned to the effect of a psychoactive drug over time.
As a result, you develop behaviors to overcome the drug’s effects.
This makes it less effective in the same amounts.
As a result, your body needs a higher dose to achieve the desired effect of the drug.
Metabolic
Metabolic tolerance results from a faster-than-normal elimination of a drug from your body.
It is linked with a specific group of liver enzymes that metabolize alcohol after chronic drinking.
This reduces the amount of time you are subject to the intoxicating effects of alcohol.
Reverse
Reverse tolerance, also called sensitization, has the opposite effect of other types of tolerance.
It occurs with drugs like psychoactive substances.
Risks
Drug tolerance interferes with a drug’s ability to deliver the intended benefit or effect.
However, it also poses several potential problems that can lead to serious results.
Never change the dose of a prescribed medication without advice from your healthcare provider.
This can occur with alcohol and both prescribed and recreational drugs.
Instead, the drug is treated as part of your body’s system.
This makes it less useful for the pain or chronic illness it treats.
Your healthcare provider can change your treatment plan to offset the effects of drug tolerance.
However, stopping or changing any medication should only be done based on the advice of your healthcare provider.
Your healthcare provider determines the best treatment for you based on this criteria.
Some of the most common types of drug tolerance are antihistamines, antibiotics, opioids, and antidepressants.
The best way to wean off of medication is under the direction of your healthcare provider.
To avoid the side effects of withdrawal, you should never stop taking medication suddenly on your own.
National Institute on Drug Abuse.The science of drug abuse and addiction: the basics.
Pietrzykowski AZ, Treistman SN.The molecular basis of tolerance.Alcohol Res Health.
2008;31(4):298-309. doi:10.1016/S0954-6111(12)70005-7
Targum SD.Identification and treatment of antidepressant tachyphylaxis.Innov Clin Neurosci.
2014;11(3-4):24-28.
2014;14(3):426-433.
2012;33(Suppl 1):S113-S141.
doi:10.2500/aap.2012.33.3603
Engin E.GABAA receptor subtypes and benzodiazepine use, misuse, and abuse.Front Psychiatry.
2019;18:1176935119881633. doi:10.1177/1176935119881633
UpToDate.Patient education: medications for angina (beyond the basics).
2012;37(1):1-7. doi:10.1007/s13318-011-0077-2
American Psychological Association.Pharmacodynamic tolerance.
2020;55(2):129-135. doi:10.1093/alcalc/agz103
American Psychological Association.Reverse tolerance.