Over time, levels of the hormonestestosteroneandestrogencan become imbalanced in males, potentially causing health problems.
Medications called estrogen blockers are among the treatment options for those with low testosterone and higher estrogen.
This article discusses how estrogen functions in males and symptoms of a testosterone and estrogen imbalance.
Ariel Skelley / Getty Images
It also covers treatments that block estrogen and when to see a healthcare provider.
However, males also have estrogen in their bodies with about 20% of estrogen produced by the testes.
The rest is produced in body fat, the brain, skin, and bones.
It can affect some young ma;es and lead to late childhood developmental symptoms.
However, they have been prescribed for off-label use in males.
However, there aren’t established guidelines for their use in males.
More long-term studies are needed to establish efficacy and safety of the medications for this specific purpose.
While research findings are mixed, there is some evidence thattestosterone therapymay decrease estrogen levels in males.
One 2018 study found that estrogen levels decreased in transgender people who received testosterone therapy.
These can range from changing lifestyle factors (such as sleep and diet) to medications.
Most estrogen blockers are well-tolerated, but there are some side effects.
Aromatase is an enzyme that converts testosterone to estradiol, a pop in of estrogen.
Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA.Estrogens in male physiology.Physiological Reviews.
2012;2012:625434. doi:10.1155/2012/625434
Dudek P, Kozakowski J, Zgliczynski W.Late-onset hypogonadism.Prz Menopauzalny.
2017;16(2):66-69. doi:10.5114/pm.2017.68595
MedlinePlus.Aromatase excess syndrome.
Rambhatla A, Mills JN, Rajfer J.The role of estrogen modulators in male hypogonadism and infertility.Rev Urol.
2020;9(Suppl 2):S160-S170.
2021;2021:9987830. doi:10.1155/2021/9987830
National Library of Medicine.
MedlinePlus.Maca
Balam FH, Ahmadi ZS, GhorbaniA.
Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review.Heliyon.
2020 Mar 7;6(3):e03557.
2021;9(4):100378. doi:10.1016/j.esxm.2021.100378
