Minocyclineanddoxycyclineare antibiotics commonly prescribed for various medical conditions.
They work by blocking bacteria’s ability to make protein.
This prevents the growth of bacteria.Antibiotics that work this way are called “bacteriostatic.”
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Minocycline and doxycycline are effective against a variety of bacteria.
They’re both in thetetracyclinefamily ofantibiotics.
Why Take Minocycline or Doxycycline?
These antibiotics are taken for specific indications, including bacterial infections and acne.
Some scenarios dictate using one versus the other.
These side effects include what are known as vestibular effects related to the inner ear.
Doxycycline hyclate is more likely to cause GI upset or ulcers.
Doxycycline can also cause photosensitivity, so be sure to use plenty of sunscreen if you spend time outside.
But they are ineffective against viruses that cause colds and flu.
Using antibiotics when you don’t need them can contribute to antibiotic resistance.
This means that bacteria learn to outsmart the antibiotics, so they stop working.
Antibiotics should be taken at the lowest effective dose and for the shortest duration possible.
Summary
Doxycycline and minocycline are broad-spectrum tetracycline antibiotics that target many of the same disease-causing bacteria.
They’re both commonly taken for acne and bacterial infections like respiratory and skin infections.
Minocycline is more likely to cause side effects than doxycycline, and these side effects can be more serious.
If you’re prescribed these or other antibiotics, follow your healthcare provider’s instructions carefully.
This will help ensure the infection is fully treated.
To minimize the risk of antibiotic resistance, take antibiotics for the shortest recommended time.
2022;54(1):1686-1700. doi:10.1080/07853890.2022.2085881
U.S. Food and Drug Administration.Doxycycline capsules prescribing information.
2021;10(7):757.
2015;2(4):ofv178.
2020;9(12):905.
2018;73(3):553-563. doi:10.1093/jac/dkx420
Laux B.Treatment of acne vulgaris.
A comparison of doxycycline versus minocycline.Hautarzt.
1989;40(9):577-581.
Navarro-Trivino FJ, Perez-Lopez I, Ruiz-Villaverde R.Doxycycline, an antibiotic or an anti-inflammatory agent?
The most common uses in dermatology.
Doxiciclina, antibiotico o antiinflamatorio?
Usos mas frecuentes en dermatologia.Actas Dermosifiliogr (Engl Ed).
2020;19(11):s6-s13.
Graber EM.Treating acne with the tetracycline class of antibiotics: a review.Dermatological Reviews.
doi:10.1002/der2.49
Singh S, Khanna D, Kalra S.Minocycline and doxycycline: more than antibiotics.Curr Mol Pharmacol.
2013;42(6):497-499. doi:10.1016/j.ijantimicag.2013.08.006
U.S. Food and Drug Administration.Minocycline hydrochloride prescribing information.
2023;40(4):1366-1378. doi:10.1007/s12325-023-02435-y
Baldwin H.Oral antibiotic treatment options for acne vulgaris.J Clin Aesthet Dermatol.
2020;13(9):26-32.
2023;17(2):281-285.
Published 2023 Feb 28. doi:10.3855/jidc.16677
U.S. Food and Drug Administration.DORYX (doxycycline hyclate) Delayed-Release Tablet prescribing information.
Centers for Disease Control and Prevention.Antibiotic use and antimicrobial resistance facts.
Newman KQ, Castles CG.Use of doxycycline in a patient following minocycline-induced lupus.Case Rep Rheumatol.
Published 2023 Jul 5. doi:10.1155/2023/7353644
American Society of Health-Systems Pharmacists.Comparison of doxycycline and minocycline.