Macrocytosisoccurs when your red blood cells (RBCs) are larger than normal and not functioning as they should.
Macrocytosis is also called megalocytosis or macrocythemia.
Macrocytosis is usually because of lowvitamin B12or folate levels.
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It can also occur with other conditions, including liver disease and cancer, or from taking certain medications.
This article discusses the symptoms and causes of macrocytosis.
It also looks at how this condition is diagnosed and treated.
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What Are the Symptoms of Macrocytosis?
Generally, macrocytosis is associated with anemia (macrocytic anemia), which is diminished RBC count.
The condition causes a decrease in oxygen delivered to the bodys tissues.
Usually, the symptoms are mild to moderate, but sometimes the effects can be severe.
Or you may have some days of feeling more worn out than others.
And illnesses, such as the common cold, can make you especially tired when you have macrocytosis.
Associated Symptoms
Often macrocytosis is accompanied by other symptoms related to its cause.
What Causes Macrocytosis?
There are several causes of macrocytosis.
The most common cause is a deficiency in vitamin B12 and folate (vitamin B9).
These two vitamins cannot be produced in the body and must come from your diet.
How Is Macrocytosis Diagnosed?
Generally, macrocytosis results from anemia, but macrocytosis without anemia also can occur.
Either way, you may need the same diagnostic tests to determine the cause.
Tests you might have:
How Is Macrocytosis Treated?
The treatment of macrocytosis centers on correcting the cause when possible.
Oftentimes, vitamin B12 and/or folate supplementation will correct the problem.
Your healthcare provider may prescribe another treatment if your macrocytosis has a different cause.
Prevention
Preventing macrocytosis generally involves making sure you get adequate nutrients in your diet.
Having regular medical checkups is important as well.
Summary
Macrocytosis means that your red blood cells are larger than normal.
It is associated with anemia, when you also have insufficient numbers of properly functioning red blood cells.
Treatment will depend on the underlying cause and may include taking in additional vitamin B12 and folate.
