Symptoms vary, depending on the stage, but can include fatigue, nausea, and foamy urine.

The symptoms of CKD develop as the kidneys are less able to filter water and waste from the blood.

The depletion of these oxygen-carrying cells is referred to asanemia.

chronic kidney disease symptoms

Illustration by Verywell

As part of an interrelated system, the loss of kidney function will invariably affect all other organ systems.

The interrelationship between the kidneys and other organs makes for health concerns that often beget other health concerns.

The consequences of these metabolic imbalances can be far-ranging and severe.

Doctor Discussion Guide Old Man

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ESRD requires that a patient getdialysisor akidney transplantto survive.

Without life-sustaining interventions, toxins can build up quickly, causing a condition called uremia.

Death usually follows within a few days to several weeks.

Summary

CKD is often due to diabetes, hypertension, or autoimmune diseases.

Symptomslike fatigue, nausea, and foamy urinemay go unnoticed until significant damage occurs.

Advanced stages can lead to severe complications, including anemia, metabolic imbalances, and organ dysfunction.

Untreated CKD may progress to end-stage renal disease (ESRD), requiring dialysis or a transplant.

Early detection and management are crucial, as symptoms are often non-specific and may resemble other illnesses.

Get our printable guide for your next doctor’s appointment to help you ask the right questions.

Adv Chronic Kidney Dis.

Medicover Hospitals.Hyperphosphatemia: Symptoms, Causes and Treatment Solutions

University of Florida Health.Renovascular hypertension.

2023 Jan 5;13(1):87. doi: 10.3390/metabo13010087.

PMID: 36677012; PMCID: PMC9863091.

Palmer BF.Sexual dysfunction in uremia.

J Am Soc Nephrol.

1999 Jun;10(6):1381-8. doi: 10.1681/ASN.V1061381.

Zemaitis MR, Foris LA, Katta S, et al.Uremia.

[Updated 2024 Mar 29].

In: StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

2017;44(1):77-88. doi:10.1159/000464347