RYR is produced by fermenting rice with a fungus (Monascus purpureus).

During fermentation, the fungus produces monacolin K. However, RYR comes with risks.

That means some supplement products may not contain what the label says.

Red yeast rice

Hendra Su / Getty Images

No supplement is intended to treat, cure, or prevent disease.

RYR has primarily been studied for its cholesterol-lowering effect.

Another review found that RYR lowered both total and LDL cholesterol in adults.

Human trials have been scarce and either small or inconclusive.

There isn’t enough evidence to recommend RYR for any of these conditions.

What Are the Side Effects of Red Yeast Rice?

Your healthcare provider may recommend taking RYR supplements to lower cholesterol or for another reason.

Remember that just because supplements are natural doesn’t mean they are safe or a good choice for everyone.

Taking a supplement like RYR may cause side effects.

These side effects can be common or severe.

Up to 23% of people who took RYR reportedmuscle symptoms.

Clinical trials of RYR’s effects on cholesterol have used doses ranging from 1,200 to 4,800 mg daily.

What Happens If I Take Too Much Red Yeast Rice?

Citrinin can be toxic to the kidneys.

The maximum daily dose of citrinin is 20 micrograms per kilogram (g/kg).

Interactions

RYR should not be taken along with statins as it could lead to an overdose.

Taking RYR with some medicines and foods can increase the risk of side effects like muscle damage.

But keep in mind that “natural” does not always mean safe.

As with other supplements, discussing taking RYR with your healthcare provider before you roll taking it is essential.

Your provider can help ensure that it won’t interact with other prescriptions or supplements you currently take.

They can also help you monitor its effect on your cholesterol levels to ensure it’s working.

Remember that monacolin K is not regulated, and results can differ dramatically between RYR products.

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