Normal BRCA1 Functions
The same genes that increase your risk of cancer also perform normal functions.
High-Penetrance Genes
High-penetrance genes increase your risk of breast cancer more than other types of genes.
People with these genes are more likely to get cancer earlier than those with nongenetic breast cancer.
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BRCA Genes
BRCA1 and BRCA2 genes are among the most important in assessing breast cancer risk.
Many other genes also occur as part of broader medical conditions.
They might increase your risk of breast cancer and multiple other medical problems, including different types of cancer.
These genes are not a standard part of genetic testing.Scientists are still researching these genes.
Not surprisingly, having two first-degree relatives with breast cancer increases your risk even more.
Having one first-degree relative with breast cancer doubles your risk, while having two almost triples it.
Breast Cancer Genetic Tests
Genetic testingis an important part of assessing breast cancer risk.
Testing is typically recommended for those predisposed to a BRCA1 or BRCA2 mutation.
Your other risk factors, insurance coverage options, and personal preferences may all play a role.
Talk to your healthcare provider about your concerns to determine what’s best for you.
Your medical history, family history, and lifestyle factors play a role in breast cancer risk.
Unfortunately, clear-cut answers arent always available.
Speak with your healthcare provider about your questions and concerns.
Together, it’s possible for you to decide on the best ways to manage your risk.
Frequently Asked Questions
No.
Moreover, most people who get breast cancer dont have a close relative who has already had the disease.
Work with your healthcare provider to assess your overall risk.
People who know they have the BRCA gene mutation have a higher risk.
But risk also increases with other factors, like age and late-onset menopause.
2019;58(2):135-146. doi:10.1080/0284186X.2018.1529428
American Cancer Society.Breast cancer risk and prevention.
Naik R, Veldore VH, Gopinath KS.Genetics and breast cancer - oncologists perspectives.Indian J Surg Oncol.
