Deficiency of immunoglobulin A (IgA) is the most common primary immunodeficiency.
It is characterized by very low to absent levels of IgA in the bloodstream.
What Is IgA?
Sam Edwards/OJO Images/Getty Images
IgA is the most abundant antibody produced by the body.
It is present in the bloodstream and it is secreted on the surface of mucous membranes.
What Is IgA Deficiency?
Slightly low IgA values are not consistent with IgA deficiency.
What Are the Symptoms of IgA Deficiency?
Most people who have IgA deficiency don’t experience any increase in infections whatsoever.
If you have possible celiac disease, you might also have a test to check for IgA deficiency.
Comorbidities
IgA deficiency is associated with an increased risk for comorbidities.
These diseases occur in approximately 20-30% of people with IgA deficiency.
Complications
GI cancers andlymphomascan occur at higher rates in people with GI disorders associated with IgA deficiency.
What Is the Treatment for IgA Deficiency?
The main treatment for IgA deficiency is the treatment of infections or of the associated diseases that may occur.
This can include treatment with antibiotics for bacterial infections.
You should have immunizations against common infections, such as the seasonalinfluenza vaccineand the pneumococcal vaccine.
However, the oral polio vaccine should not be given to people with selective IgA deficiency.
Discuss your options with a healthcare provider.
GI diseases, allergic conditions, and worsening immunodeficiency.
Immune Deficiency Foundation.Selective IgA deficiency.
Yel L.Selective IgA deficiency.J Clin Immunol.
2010 Jan;30(1):10-6. doi:10.1007/s10875-009-9357-x
