Both drugs can be used to treatpostherpetic neuralgia(a chronic pain disorder caused byshingles).

Gabapentin acts directly on targets in the brain called adenosine receptors.

These receptors releaseneurotransmitters(chemical messengers) calleddopamineandglutamatethat have an opposite effect to GABA, causing nerve excitement.

A man sitting on his bed with restlessness

PhotoAlto / Fredric Cirou / Getty Images

How Long Does Gabapentin Take to Work?

Numerous studies have evidenced the effectiveness of gabapentin for the treatment of restless legs syndrome.

Gabapentin is relatively fast-acting and can start to ease symptoms within one to two hours.

Horizant comes in tablet form and is taken once daily in a single 600-milligram (mg) dose.

To avoid side effects like dizziness and upset stomach, it is taken with your evening meal.

Neurontin is available as a capsule, tablet, and oral solution.

Some people may experience no side effects at all.

Both are potentially deadly.

Other rare but potentially serious side effects include

Call your healthcare provider immediately if any of these occur.

With that said, never stop treatment until you speak with your healthcare provider.

Summary

Gabapentin is a prescription drug used to treat restless leg syndrome (RLS).

Common side effects include dizziness, upset stomach, diarrhea, or constipation.

2016:16(11):12631277. doi:10.1080/14737175.2016.1202764

National Library of Medicine.Gabapentin.

National Institute of Neurological Disorders and Stroke.Restless legs syndrome.

GlaxoSmithKline.Horizont (gabapentin enacarbil) extended-release rablets for oral use.

Pfizer.Neurontin (gabapentin) capsules, for oral use.