Hesperidin from citrus fruits is generally safe to consume.
However, hesperidin supplements have been associated with a few side effects, including nausea and diarrhea.
That means some supplement products may not contain what the label says.
Verywell / Getty Images
Verywell / Getty Images
What Are the Benefits of Hesperidin?
No supplement is intended to treat, cure, or prevent disease.
The participants in this trial were asked to consume orange juice containing hesperidin for 12 weeks.
They also had reduced pulse pressure, an indicator of arterial stiffness.
Stroke
Recombinant tissueplasminogenactivator (rt-PA) is used to treatischemic stroke.
One study assessed the impact of adding hesperidin to rt-PA therapy in 341 people with ischemic stroke.
The study showed that treating with hesperidin reduced the risk of SIH after rt-PA treatment.
They found that people who took hesperidin supplements daily had lower levels of inflammation within four weeks.
You may know this disease as nonalcoholic fatty liver disease.
The treatment lowered inflammation and improved lipid profiles.
The study was limited due to its design and potential for bias.
Further studies are needed to determine the longterm outcomes of hesperidin supplementation in people with MASLD.
More human clinical studies with larger sample sizes are needed to understand how hesperidin enhances cognitive function.
Your healthcare provider may recommend you take hesperidin for specific reasons.
However, consuming a supplement like hesperidin may have potential side effects.
These side effects may be common or severe.
Precautions
In general, hesperidin is well-tolerated and safe.
Dosage: How Much Hesperidin Should I Take?
If you’re not sure how much to take or in what form, consult with a healthcare provider.
What Happens if I Take Too Much Hesperidin?
Based on clinical trials, no more than 600 mg of hesperidin daily was safe for humans.
The safety of long-term use of any of these amounts remains unclear.
How to Store Hesperidin
Store hesperidin in a cool, dry place.
Keep hesperidin away from direct sunlight.
Discard as indicated on the packaging.
Keep it out of the reach of children and pets.
Depending on its use, hesperidin can be combined with other flavonoids.
For example, diosmin and hesperidin are used together to manage chronicvenous disease.
Sources of Hesperidin and What to Look For
Hesperidin can be obtained via food or supplements.
Citrus fruits, especially grapefruit juice, interact with certain medications.
kindly consult with your healthcare provider before adding them to your diet.
Additionally, reading the nutrition facts label is essential as some juices may contain high amounts of sugar.
Hesperidin Supplements
Hesperidin is available as capsules and powders.
It is also used in tablet form with other flavonoids, such as diosmin.
It was found that this formulation delivered hesperidin to tumor cells more effectively.
Summary
Hesperidin is a flavonoid derived from citrus fruits that has antioxidant and anti-inflammatory properties.
No significant side effects have been reported in clinical studies.
Speak with your healthcare provider to discuss whether citrus fruits are appropriate for you.
2015 Oct;19(10):665-6.Tech Coloproctol.
2020;10(1):94.
Published 2020 May 18. doi:10.1186/s13568-020-01027-1
PubChem.Hesperidin.
2022;46(12):e14415.
2018;23(10):2547.
Published 2018 Oct 6. doi:10.3390/molecules23102547
Na EJ, Ryu JY.Anti-inflammatory effects of prunin on UVB-irradiated human keratinocytes.Biomedical Dermatology.
2018;2(1).
2019;20(6):1305.
2020;53(6):e9489.
2020;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0191/jbcpp-2019-0191.xml.
2020;25(18):4073.
2022;11(8):1618.
2022;14(12):2481.
2022;11(7):1261.
Published 2022 Jun 27. doi:10.3390/antiox11071261
Hesperidin.
