The genetics of non-celiac gluten sensitivity is far less clear.
There are four general types of HLA-DQ genes, known as HLA-DQ1,HLA-DQ2, HLA-DQ3, and HLA-DQ4.
Some of these genes predispose you to celiac disease, while other genes may predispose you to gluten sensitivity.
Ippei Naoi / Getty Images
Dr. Fasano currently is working to identify biomarkers that could lead to a test for gluten sensitivity.
But those with HLA-DQ2 and HLA-DQ8 aren’t alone in their gluten sensitivity, Dr. Fine says.
He believes everyone with HLA-DQ1 and HLA-DQ3 also is predisposed to having gluten sensitivity.
In his opinion, the rest have the genetic potential to develop the condition.
However, since not everyone does have the condition (see my article How Many People Have Gluten Sensitivity?
), there must be other factors and genes involved.
2011 Mar 9;9:23. doi:10.1186/1741-7015-9-23
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