Tony Anderson / Getty Images
Collagen and biotin are popular supplements for healthy hair, skin, and nails.
Some people may benefit from taking both.
For Skin Health
Collagenis more directly involved in skin health than biotin, particularly for aging-related concerns.
Tony Anderson / Getty Images
Collagen levels decline with age, causing skin to lose firmness and moisture.
It helps your body producekeratin, the protein that makes up hair, skin, and nails.
A lack of biotin can lead to thinning hair or hair loss.
What Does Collagen Do?
It is the main structural protein in humans, making up about 30% of all proteins.
Taking a collagen supplement can help replace what your body no longer makes.
What Does Biotin Do?
The benefits of biotin include:
Unlike collagen, your body does not produce biotin.
Certain medications, such as anticonvulsants (anti-seizure drugs), may increase your risk of biotin deficiency.
In fact, some supplements combine biotin and collage into one product.
Side Effects
Collagen and biotin are generally safe for most people when taken as directed.
These supplements may trigger allergic reactions, such asanaphylaxis, a severe, even life-threatening reaction to a substance.
Biotin is not known to cause side effects in most people, even when taken in large amounts.
Its a water-soluble vitamin, so excess amounts are usually passed through the urine.
If you are taking a biotin supplement, inform your provider before getting lab work to avoid incorrect results.
it’s possible for you to safely take both.
A healthy diet with collagen- and biotin-rich foods can also improve skin and hair health.
2022;12(1):e2022018.
doi:10.5826/dpc.1201a18
National Institutes of Health, Office of Dietary Supplements.Biotin - health professional fact sheet.
Deshmukh SN, Dive AM, Moharil R, et al.Enigmatic insight into collagen.J Oral Maxillofac Pathol.
2023;15(9):2080. doi:10.3390/nu15092080
Saleem F, Soos MP.Biotin deficiency.
In:StatPearls.StatPearls Publishing; 2025.
Patel DP, Swink SM, Castelo-Soccio L.A review of the use of biotin for hair loss.Skin Appendage Disord.
2024;33(7):e15137.
2021;53(10):1493-1506. doi:10.1007/s00726-021-03072-x
Manon-Jensen T, Kjeld NG, Karsdal MA.Collagen-mediated hemostasis.J Thromb Haemost.
2019;18(1):9-16.
2025;24(2):e16688.
2018;6(10):2325967118804544. doi:10.1177/2325967118804544
MedlinePlus.Biotin.
2024;17:581-591. doi:10.2147/CCID.S438642
Martini N.Collagen supplements.J Prim Health Care.
2016;65(4):474476. doi: 10.1016/j.alit.2016.03.012.
2019;11(5):1079. doi:10.3390/nu11051079
