Acute and Progressive Symptoms of Bile Duct Inflammation
Cholangitisis a liver disease that involves inflammation of your bile ducts.
These tubes carrybilefrom yourliverandgallbladderinto yoursmall intestine.
Bile is a digestive liquid made by your liver that helps digest fats and fatty vitamins.
As bile backs up, it harms your bile ducts, causingcirrhosis, or scars in your liver tissue.
This permanently slows liver function.
Cholangitis can occur as a chronic or acute problem.
Chronic cholangitis results in a slow decline of liver function leading toliver failure.
The acute version needs urgent care.
It can threaten your life if treatment is given too late.
This article describes cholangitis symptoms, types, treatments, and ways to manage this disease.
Symptoms of Cholangitis Bile Duct Inflammation
Symptoms of cholangitis bile duct inflammation can vary by individual.
It develops as a result of an infection.
Treatment includes addressing the infection and obstruction of the bile duct.
The following therapies are used:
Why Do Cholangitis Infections Develop?
Cholangitis infections can be a chronic or acute problem.
Early treatment can increase your chances of a rapid and full recovery.
Recovery typically involves the following outcomes with these treatments:
Antibiotics
People treated with antibiotics often feel better quickly.
Hospitalization may be necessary if you require treatment with intravenous (IV) antibiotics.
The success of this treatment depends on how quickly the medications are administered after symptoms begin.
The best results occur when antibiotics are started as soon as possible.
ERCP
After an ERCP, you may go home the same day or stay overnight in the hospital.
You may feel the discomfort of bloating after the procedure.
A hospital stay is likely if you have an infection so IV antibiotics can be administered.
Recovery from an ERCP usually involves rest for at least 24 hours after your procedure.
Gallbladder Surgery
Recovery from gallbladder surgeryvaries depending on the throw in of surgery used.
This procedure can be performed via open surgery or with minimally invasive approaches like laparoscopy or robotic-assisted techniques.
Open surgery always requires a hospital stay and about four to six weeks to return to normal activities.
These procedures may allow you to return to normal activities within one to two weeks.
Alone, chronic cholangitis progresses gradually, often leading to liver failure within about 10-15 years after diagnosis.
However, commodities can worsen this prognosis.
Of these people up to 20% will have two or more additional autoimmune conditions.
People with a PBC liver often have a quality of life that is lower than others.
Chronic cholangitis leads to liver failure.
The criteria for getting on a liver transplant list can vary by transplant center.
The severity of your condition is assessed based on theModel for End-Stage Liver Disease (MELD) score.
The sickest people have the highest MELD scores.
Summary
Cholangitis describes an acute or chronic disease that damages your bile ducts.
These issues cause scars to form inside the tubes that allow the flow of bile from your liver.
In its chronic form, the problem slowly leads to liver failure.
When it occurs as an acute problem, it needs emergency care to prevent sepsis, a life-threatening illness.
Symptoms of abdominal pain, jaundice, and fever can be signs of an acute problem.
Prompt treatment can improve your outcomes for any form of this disease.
The earlier antibiotics are given and clogged ducts are cleared, the better your chances of avoiding sepsis.
Early diagnosis and treatment can also help protect liver health and possibly slow disease progress of the chronic form.
Mohammad Alizadeh AH.Cholangitis: diagnosis, treatment and prognosis.J Clin Transl Hepatol.
2017;5(4):404-413. doi:10.14218/JCTH.2017.00028
BMJ Best Practice.Acute cholangitis.
Ahmed M.Acute cholangitis - an update.World J Gastrointest Pathophysiol.
WakeMed.ERCP: what to expect.
Kaiser Permanente.Gallbladder removal surgery:what to expect at home.
American Liver Foundation.Primary sclerosing cholangitis (PSC).
2021;17(2 Suppl 3):9.
American Liver Foundation.Have PCBC?
You may be at risk for another autoimmune disease.
UpToDate.Liver transplantation in primary biliary cholangitis.
Goldberg DS.Liver transplant in patients with primary sclerosing cholangitis.Gastroenterol Hepatol (N Y).
2016;12(2):127-129.
UPMC.What is a MELD score?
National Institute of Diabetes and Digestive and Kidney Diseases.The liver transplant process.