Whether you experience stomach upset while taking Advil may also depend on individual risk factors.

Do you gotta Take Advil With Food?

If this occurs, you might take it with food or a glass of milk to prevent stomach upset.

Close up top view of Advil (ibuprofen) tablets in a bottle

Getty Images /Bloomberg/ Contributor

Advil blocksprostaglandinsynthesis (the process of producing the pain-associated molecules prostaglandins) to decrease pain and inflammation.

However, the onset of the drug’s action may decrease when you take it after food.

A few precautionary measures can help decrease the adverse effects of Advil.

If possible, take ibuprofen in low doses (less than 1,200 mg daily in divided doses).

This is milder for the GI tract and can be used longer.

you’re able to even take it on an empty stomach.

pylorican also help prevent ulcers in people with a history of peptic ulcer disease before starting low-dose NSAIDs.

This test is not usually recommended for people without symptoms.

However, it may be recommended for people with a previous ulcer history to start low-dose NSAIDs.

Is Advil or Tylenol Easier on the Stomach?

Tylenol (acetaminophen)is generally a mild and safe painkiller.

When used as directed, it is gentler on the stomach than Advil.

It typically does not cause GI side effects.

Advil may cause side effects to the GI tract.

The risk of these side effects is higher for people with a history of stomach ulcers or older adults.

These side effects may include:

GI irritation is one of Advil’s most common side effects.

It is associated with its mechanism of action.

Advil blocks the synthesis of prostaglandins andCOX (cyclooxygenase) enzymes.

The reduction in the mucosal levels of prostaglandins later damages the stomach and small intestine.

COX inhibition in the GI tract also inhibits the production of gastric mucus and bicarbonate.

These reduce cell proliferation and promote adequate blood flow throughout the GI mucosa.

Call your healthcare provider if you experience constant pain and other symptoms.

Different precautionary measures can be taken to prevent these adverse effects.

Taking your dose with a meal might help.

Always consult your healthcare provider if you have any severe symptoms.

2023;15(4):e37080.doi:10.7861/clinmed.2021-0039