Typically, Botox blocks chemical signals from nerves that cause muscles in the treated area to contract.
This paralyzes the muscles, preventing movements that cause wrinkles to form.
Botox injections arenot without risk.
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Side effects range from bruising and redness at the injection site to headaches andallergic reactions.
Also, Botox may not be effective for everyone.
After repeated use, some people may become immune to its wrinkle-reducing effects.
This article covers what happens when Botox doesn’t work and why some people become immune to it.
It also addresses reasons why botox injections fail, and what to do if yours don’t work.
What Happens When Botox Doesn’t Work
Botox doesn’tsmooth wrinklesimmediately.
When Botox is done correctly, the treated muscles should become completely paralyzed.
If you are Botox-resistant, this won’t be the case.
These antibodies fight off the proteins in Botox and counteract their effects.
As a result, the Botox may partially or completely fail to paralyze the treated muscles.
Botox resistance is most likely to occur in people who receive higher doses of Botox.
The packaging for Botox and Botox Cosmetic notes that the immune reaction which causes Botox resistance is a risk.
Summary
If Botox ain’t running for you, you may have developed Botox resistance.
Immunity to Botox happens when the immune system develops antibodies that neutralize Botox proteins, rendering them ineffective.
Botox treatment may also fail if a provider uses improper technique.
Receiving treatments from an experienced, board-certified provider increases your chances of successful Botox injections.
2019 Apr;12(1):223-228. doi:10.2147/CCID.S202919
American Society of Plastic Surgeons.How long does botox last?.
2022 Jun;10(6):e4407.
2016 Jun;263(6):1188-1194. doi:10.1007/s00415-016-8136-x
Food and Drug Administration.BOTOX Cosmetic (onabotulinumtoxinA) for injection.
Clinical-electrophysiological findings and tips on safety in different neurological disorders.Front Pharmacol.
2015 Dec 1;107(Pt A):72-6. doi:10.1016/j.toxicon.2015.09.037.
2014 Dec;13(4):346-8. doi:10.1111/jocd.12108
