However, other people are at risknot only people with MS.

They may include:

Even though PML is an infection, it doesn’t usually cause a fever.

Early diagnosis offers you the best chance for a good outcome should you develop this disease.

What Is Progressive Multifocal Leukoencephalopathy (PML)?

Alex Dos Diaz / Verywell

Interferons such asAvonex (interferon beta-1a)andBetaseron (interferon beta-1b)do not increase the risk of PML.

And corticosteroids, which are used during an MS exacerbation, are also not associated with PML.

Other people (not just MS patients) get PML.

What to expect during the JC virus antibody test

Verywell / Cindy Chung

Diagnosis

The symptoms of PML are often similar to those of an MS relapse.

However, these are simply clues, not hard-and-fast rules.

They may be described as atypical, diffuse, or patchy.

In some instances, a brain biopsy is done to examine an area of abnormality in the brain.

Survivors are highly likely to experience long-term consequences, such as personality changes, seizures, and neurological deficits.

Additional therapies for these issues are likely.

Plasmapheresis is a process of plasma exchange.

However, note that maraviroc is currently only an experimental drug at this time.

Keep in mind that about 80% of the population has JC-Virus antibodies, so testing positive is expected.

As with any condition, early intervention is key.

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