Lac-Phe is naturally produced after intense exercise and suppresses appetite and food intake, which leads to weight loss.
Exercise and metformin both have multiple different beneficial effects, and weight loss is one of them.
Stanford Medicine researchers first discovered Lac-Phe in 2022 while studying exercise and metabolism-related molecules.
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Lac-Phe levels increased in mice, racehorses, and humans after exercise.
What Does this Mean for Weight Loss Drug Development?
Were looking for the cellular targets of Lac-Phe on those appetite control neurons.
And I think we are making good progress, Xiao said.
Semaglutide works pretty well to reduce body weight, Xiao said.
Some people are resistant and dont really lose body weight in response to that.
Right now, it seems the diabetes drug metformin can boost Lac-Phe production.
But metformin can cause a serious condition called lactic acidosis.
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