Antihistamines like Allegra, Zyrtec, and Claritin work by blocking histamines and calming your allergic response.

Zyrtec works quickly for the treatment ofallergic rhinitisand hives, typically within less than an hour.

You should follow the medication’s label unless advised to do so by your physician.

Doctor talking with patient at desk in office

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Many people do not experience any fatigue on Zyrtec; others report fatigue with Allegra.

They can determine the next steps, which may includeallergy shots.

Allegra vs. Zyrtec vs. Claritin: Which Makes You Sleepier?

First-generation antihistamines such asBenadrylcross theblood-brain barrier, which can produce a sedative effect.

This happens because histamines found in the brain also play a role in keeping you awake.

Zyrtec is more likely to make you sleepy than Allegra or Claritin.

Be sure to speak with your healthcare provider about potential drug interactions when you take antihistamines.

Drug Forms

Antihistamines are available in several different over-the-counter products.

They include:

Some options, including the chewables and syrups, are designed for children.

Your pediatrician can help you to decide which products will work best for achild with allergies.

Allegra can be used in children as young as 6 months old.

Always Read Drug Labels

Antihistamines are safe when they’re used as directed.

They can be dangerous when used improperly or carelessly.

For example, some medications that contain antihistamines also contain pain medication.

However, these drugs don’t share all of the same potential side effects.

It is possible, though uncommon, to have an allergic reaction to an antihistamine.

Allegra vs. Zyrtec vs. Claritin: Possible Interactions

Not all antihistamines are recommended for all people.

Juices such as orange juice or grapefruit juicecan decrease the absorption of Allegraby nearly half.

Zyrtec and Claritin are preferred during lactation over Allegra.

But some differences between them may make one of these antihistamines better for you than the others.

For example, Zyrtec may work faster than Claritin and Allegra.

While all three can make some people a little sleepy, Allegra is the least likely to.

If you’re unsure which antihistamine to select, consult your healthcare provider or pharmacist.

Published 2019 Oct 1. doi:10.1186/s13223-019-0375-9

Claritin.Claritin FAQ.

American Academy of Allergy Asthma & Immunology.Antihistamines: If/when are first generation medications advantageous over newer antihistamines?

American Academy of Family Physicians.Antihistamines.

National Capital Poison Center.Safe use of antihistamines.

Gonzalez-Estrada A, Geraci S.Allergy medications during pregnancy.Am J Med Sci.

U.S. Food & Drug Administration.Zyrtec Allergy (cetirizine HCl) orally disintegrating tablets, 10 mg drug approval package.