There are two formulations of Adderall: Adderall extended-release (XR) and Adderall immediate-release (IR).

This article compares the similarities and differences between Adderall IR and Adderall XR.

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Adderall XR vs. IR: What Are the Differences?

A close-up of 25-milligram Adderall XR prescription pill bottle

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Extended-release or “XR” medications release a drug slowly into the body over a period of time.

Immediate-release or IR medications, on the other hand, release a drug into your body right away.

Adderall IR is a short-acting formulation that generally lasts for about four to six hours.

The following table highlights the main similarities and differences between Adderall IR and Adderall XR.

Dosing for Adderall XR vs. IR

Adderall IR is available in tablets.

Avoid taking it late in the evening to prevent trouble sleeping.

Adderall XR is available in capsules.

Capsules can be swallowed whole with water or other liquids.

It can be taken with or without food.

Use all medicine as directed on your prescription label and read all medication guides.

Tell your healthcare provider immediately if you notice the emergence or worsening of any of these side effects.

Adderall IR and Adderall XR are habit-forming medications.

Improper use of stimulants like Adderall can lead to overdose and death.

Tell your healthcare provider if you have had problems with substance use disorder in the past.

Who Should Take Adderall XR vs. IR?

Summary

There are two formulations of Adderall: Adderall XR and Adderall IR.

Both are taken for treating ADHD, while Adderall IR is additionally taken for treating narcolepsy.

Adderall XR is long-acting, while Adderall IR is short-acting.

Your healthcare provider will choose between IR or XR formulation depending on your or your childs needs.

U.S. Food and Drug Administration.Adderall XR label.

2019;29(5):324-339. doi:10.1089/cap.2019.0043