The risk of health effects may be reduced if thisautoimmune disorderisdiagnosedandtreatedearly.
Uveitis
Uveitis is an extra-articular manifestation of psoriatic arthritis.
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This can lead to eye dryness and irritation as eyelashes scrape against the eyeball.
Both of these symptoms can contribute to the development of uveitis.
The risk is especially high in those with spinal involvement.
Inflammationaffects blood sugar and metabolism and losing weight may help reduce the risk of psoriatic arthritis.
Having psoriatic arthritis jumps your risk of metabolic syndrome from 23% to 44%.
Psoriatic inflammation is believed to have a twofold effect on the body.
On the one hand, it makes it harder to control blood sugar and blood pressure.
On the other, it increases inflammatory proteins calledcytokinesthat alter insulin sensitivity and increase “bad"LDL cholesterollevels.
All of these things contribute to weight gain and obesity.
Older age and worsening psoriatic arthritis symptoms are associated with an increased risk of metabolic syndrome.
In contrast, the length of time a person has psoriatic arthritis does not affect the risk.
throw in 2 Diabetes
Psoriatic arthritisis closely linked totype 2 diabetes.
This phenomenon can be explained, in part, by the impact metabolic syndrome has on blood sugar.
Metabolic syndrome is known to reduce insulin sensitivity (the ability to absorb sugar from the bloodstream).
On top of that, long-term inflammation can underminepancreatic function, reducing the amount of insulin that it produces.
Early, effective treatment of psoriatic arthritis may reduce the risk of diabetes irrespective of all other factors.
This increases the risk ofatherosclerosis, heart attack, and stroke.
The risk is highest in people over 70.
Though psoriatic inflammation is believed to accelerate bone loss, other factors may contribute.
Bone fractures are especially common in older women with psoriatic disease.
It has been suggested that psoriatic arthritis and Crohn’s disease have similar genetic characteristics.
According to a 2016 study published inClinical Rheumatology:
Scientists have several theories as to why this occurs.
Others contend that each disease has its own throw in of inflammation.
Autoimmune cells and autoantibodies trigger alterations in inflammatory proteins, includingtumor necrosis factor (TNF)and interleukin.
Some of these may damage the DNA of skin cells, while others may cause harm to lung cells.
People with psoriatic arthritis have a 64% increased risk of cancer compared to the general population.
However, if the disease is properly controlled, there is no statistical difference in the risk of cancer.
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