More serious side effects, such as bone loss, can also occur with use.
Depo-Provera is an injection that is given every 12 weeks.
Irregular Menstrual Bleeding
Menstrual cycle changes are the most common side effects of the Depo-Provera shot.
Verywell / Emily Roberts
Many individuals stop using it within the first year because of irregular spotting or bleeding.
This side effect can last more than a year for some people.
In some cases, ending the treatment is the only option.
No Periods
After a few shots, Depo-Provera may stopmenstruationaltogether in some people.
Others may have very light periods.
This is often considered a positive side effect of the Depo shot.
Clinical studies estimate that over a third of those on Depo-Provera will stop menstruating after six months of treatment.
This number increases to 55% of individuals after a year and 68% by year two.
Many are willing to tolerate the initial bleeding with the hopes of not having a period anymore.
If you have a history of depression, you should be monitored for mood-related side effects while using Depo-Provera.
If you experience symptoms of depression, discontinue use.
That number increased to 8 pounds by year two and continued to increase.
This side effect is not seen in everyone, however.
Delayed Fertility
Depo-Provera has a long-lastingbirth control effect.
Once stopped, it may take up to a year to start ovulating normally again.
According to research, 68% of women were able to get pregnant within 12 months after stopping Depo-Provera.
By 15 months, this increased to 83%.
By 18 months, 93% of those who wanted to get pregnant were able to do so.
If you have severe abdominal pain while using this form of birth control, seek emergency care at once.
Ectopic pregnancy is a life-threatening emergency.
Headache
Some people taking Depo-Provera experience headaches.
During clinical trials, this side effect was reported by 16.5% of subjects.
These reactions tend to be relatively minor and resolve on their own within a day or two.
Summary
Depo-Provera is a progestin-based birth control shot.
Some may also experience headaches, dizziness, and fatigue.
Be sure to discuss any concerns with your doctor.
Frequently Asked Questions
Most side effects from Depo-Provera go away within two to three months.
Depo-Provera is safe for most people.
Hormonal birth controlmay cause fatigue.
One study showed a link between hormonal birth control use,insomnia symptoms, and daytime sleepiness.
Most Depo-Provera side effects can be treated.
Abnormal vaginal bleeding may be treated with oral estrogen supplementation.
Weight gain may be averted through a healthy, low-fat diet and regular exercise.
Bone thinning may be fully or partially reversed by stopping Depo-Provera.
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