eternalcreative / Getty Images

L-5-hydroxytryptophan(5-HTP) is an amino acid that the body makes from tryptophan.

5-HTP supplements are taken for benefits such as boosting mood, improving sleep, and fighting fatigue.

Don’t throw away your prescription bottles just yet.

Young woman holding a glass of water and a supplement in the kitchen

eternalcreative / Getty Images

Migraine Help

Migraine is a common brain condition that’s thought to be linked to low levels of serotonin.

Although 5-HTP could theoretically boost energy by increasing serotonin, there’s currently very little evidence it does.

A study of 48 active adults concluded that taking 5-HTP for eight weeks decreased body fat andimproved body composition.

Interestingly, after eight weeks, the benefits of 5-HTP for sleep seem to level off.

How Much Should I Take?

The optimal dose of 5-HTP is unclear.

It hasn’t been studied well or often, and dosage ranges have varied widely.

As a result, some supplement products may not contain the ingredients listed on the label.

Whenchoosing a supplement, look for products independently tested or certified by organizations such asNSF,U.S.

Pharmacopeia(USP), orConsumerLab.com.

Summary

5-HTP is an amino acid that the body converts into the hormones melatonin and serotonin.

Advertised benefits of 5-HTP supplements include improved sleep, mood, and body composition.

However, very little evidence supports 5-HTP for these or other uses.

Side effects of 5-HTP range from mild (stomach upset) to severe (serotonin toxicity).

Discuss the use of this supplement with your healthcare provider before taking it.

2020;22(1):181.

2022;163(5):1294-1305.e3.

doi:10.1053/j.gastro.2022.07.052

Sarzi Puttini P, Caruso I.Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study.J Int Med Res.

2021;5(Suppl 2):372.

2018;64(10):720-727.

Tripathi R, Bano H, Alam MR.Case report on melatonin overdose: cause and concern.Sleep Med X.

Published 2019 Sep 9. doi:10.1177/1178646919873925