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L-5-hydroxytryptophan(5-HTP) is an amino acid that the body makes from tryptophan.
5-HTP supplements are taken for benefits such as boosting mood, improving sleep, and fighting fatigue.
Don’t throw away your prescription bottles just yet.
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Migraine Help
Migraine is a common brain condition that’s thought to be linked to low levels of serotonin.
Although 5-HTP could theoretically boost energy by increasing serotonin, there’s currently very little evidence it does.
A study of 48 active adults concluded that taking 5-HTP for eight weeks decreased body fat andimproved body composition.
Interestingly, after eight weeks, the benefits of 5-HTP for sleep seem to level off.
How Much Should I Take?
The optimal dose of 5-HTP is unclear.
It hasn’t been studied well or often, and dosage ranges have varied widely.
As a result, some supplement products may not contain the ingredients listed on the label.
Whenchoosing a supplement, look for products independently tested or certified by organizations such asNSF,U.S.
Pharmacopeia(USP), orConsumerLab.com.
Summary
5-HTP is an amino acid that the body converts into the hormones melatonin and serotonin.
Advertised benefits of 5-HTP supplements include improved sleep, mood, and body composition.
However, very little evidence supports 5-HTP for these or other uses.
Side effects of 5-HTP range from mild (stomach upset) to severe (serotonin toxicity).
Discuss the use of this supplement with your healthcare provider before taking it.
2020;22(1):181.
2022;163(5):1294-1305.e3.
doi:10.1053/j.gastro.2022.07.052
Sarzi Puttini P, Caruso I.Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study.J Int Med Res.
2021;5(Suppl 2):372.
2018;64(10):720-727.
Tripathi R, Bano H, Alam MR.Case report on melatonin overdose: cause and concern.Sleep Med X.
Published 2019 Sep 9. doi:10.1177/1178646919873925